USP7 anticorps

N° du produit ABIN966249

Cet anticorps anti-USP7 est un anticorps Souris Monoclonal détectant USP7 dans WB et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 3+ publications.

Aperçu rapide pour USP7 anticorps (ABIN966249)

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 5F11

Détail du produit anti-USP7 anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human HAUSP expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-USP7 (ABIN966249)

Kotoula, Krikelis, Karavasilis, Koletsa, Eleftheraki, Televantou, Christodoulou, Dimoudis, Korantzis, Pectasides, Syrigos, Kosmidis, Fountzilas: "Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)." dans: BMC cancer, Vol. 12, Issue 1, pp. 342, (2012) (PubMed).

Abély: "[Treatment of airway inflammation in cystic fibrosis]." dans: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Vol. 14, Issue 11, pp. 1350-5, (2007) (PubMed).

MILLER: "Observations on a case of probable bone marrow anthracosis." dans: Blood, Vol. 14, pp. 1350-3 (PubMed).

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: HAUSP

Sujet: USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP acitivity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.Normally, p53 levels are kept low in part due to Mdm2mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
Synonyms: TEF1, HAUSP, USP7

Poids moléculaire: 128kDa

ID gène: 7874